Dr. Mohammed Kalimi
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Contact Information
Department of Physiology and Biophysics Virginia Commonwealth University P.O. Box 980551 Richmond, Virginia 23298-0551 Tel: 804-828-9500 Fax: 804-828-7382 email: mkalimi@vcu.edu |
Mohammed Y. Kalimi obtained his B.S. in Chemistry from Bombay University, where he also completed his M.S. in 1964 and Ph.D. in 1970 in Biochemistry. He undertook his post doctoral training with Dr. Feigelson at Columbia University, and with Dr. B. O’Malley at Baylor College of Medicine. After serving on the faculty at the Albert Einstein College of Medicine. Dr. Kalimi joined the department in 1979.
Teaching
Currently I am devoting the majority of my time to the education of graduate and professional students. In the School of Medicine, I direct the Graduate Mammalian Physiology course (PHIS 501) and the Graduate Student Seminar course (PHIS 691-003). I also participate in graduate and undergraduate medical teaching (endocrinology, reproduction, and chemical signaling).I have received the following Teaching recognitions:
Teaching Award- MI students- 1980, 1985, 1986, 1987, 2000.
Physiology Graduate Students Recognition Award- 1990, 1991, 1992
Research
My research interest involved the understanding of the molecular mechanism of the rat hepatic glucocorticoid receptor activation process and regulation of glucocorticoid receptors under various pathophysiological conditions. In addition, I am interested in the elucidation of the biological role of the adrenal cortex hormone, dehydroepiandrosterone (DHEA) and protective effects of steroids against various neurotoxic agents using mouse clonal hippocampal (HT-22) cells.
Calorie restriction (reducing food intake by roughly a third while maintaining adequate nutrition) extends life span in diverse species. Since the effectiveness of calorie restriction depends on degree and length of restriction required, it is important to identify compounds that potentiate calorie restriction effects by targeting stress responses and metabolic pathway affected by calorie restriction. In this regards, the development of the calorie restriction memetics agents which retard the onset of age-related diseases and resistance to stress effects of calorie restriction is a major focus of my current research endeavor using rats.
I have received the following Research recognition:
Research Career Development Award, National Institutes of Health, 1980-85
At the present time no training opportunities are available in my laboratory for PhD studies.
Selected Publications
Original Work
Kalimi M, and Gupta S Physicochemical characterization of rat liver glucocorticoid receptor during development. J Biol Chem. 257:13324-28, 1982. PubMed
Regelson W., Loria R and Kalimi M: Beyond abortion: RU 486 and the needs of the crisis constituency , JAMA, 264, 1026-27, 1990. PubMed
Shafagoj Y, Opoku J, Regelson W, Qureshi D and Kalimi M: Dehyroepiandrosterone(DHEA) prevents dexamethasone-induced hypertension in rats. Am J Physiol, 263, E210-13, 1992. PubMed
Cardounel A, Regelson W, and Kalimi M: Dehydroepiandrosterone protects hippocampal neurons against neurotoxin-induced cell death: mechanism of action. Proc Soc Exp Biol Med, 222: 145-49, 1999. PubMed
Gursoy E, Cardounel A, Hu Y, and Kalimi M: Biological effects of long-term caloric restriction: adaptation with simultaneous administration of caloric stress plus repeated immobilization stress in rats. Exp Biol Med, 66: 96-02, 2001. PubMed
Al-Khlaiwi T, Al-Dress A, Gursoy E, Qureshi I, Biber T. and Kalimi M: Estrogen protects cardiac myogenic (H9c2) rat cells against lethal heat shock-induced cell injury. Cardiovascular Pharmacology, 45: 217-24, 2005. PubMed
Books
Hubbard, J. Kalimi, M. and Witorsch, R. Review of Endocrinology and Reproduction, Renaissance Press, 1986.
Kalimi, M. and Hubbard, J. Peptide Hormone Receptors, Walter de Gruyter, 1987.
Kalimi,M.and Regelson,W. Biological Effects of Dehydpepiandrosterone, Walter de Gruyter,1990.
Kalimi M, and Regelson W. Dehydroepiandrosterone (DHEA). Biochemical, Physiological and Clinical Aspects. Walter de Gruyter,2000.